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Forbes currently ranks Bezos as the worldвЂ™s richest person, with a net worth of around $200 billion.

That paradox is one that people like Milner, age 59, and Bezos, who is 57 years old, may feel acutely. ItвЂ™s been said that young people dream of being rich, and rich people dream of being young. вЂњAlthough there are many hurdles to overcome, there is huge potential,вЂќ Yamanaka said in an email, in which he confirmed his role in Altos. Depending on how much reprogramming occurred, some mice developed ugly embryonic tumors called teratomas, even as others showed signs their tissues had become younger.

The results of such mouse experiments, while tantalizing, were also frightening. By 2016, IzpisГєa BelmonteвЂ™s lab had applied these factors to entire living mice, achieving signs of age reversal and leading him to term reprogramming a potential вЂњelixir of life.вЂќ YamanakaвЂ™s breakthrough discovery was that with the addition of just four proteins, now known as Yamanaka factors, cells can be instructed to revert to a primitive state with the properties of embryonic stem cells. Shinya Yamanaka, who shared a 2012 Nobel Prize for the discovery of reprogramming, will be an unpaid senior scientist and will chair the companyвЂ™s scientific advisory board. Salk declined to comment.ДЄlso joining is Steve Horvath, a UCLA professor and developer of a вЂњ biological clockвЂќ that can accurately measure human aging. Calico has also started a lab whose focus is reprogramming it published its first preprint on the topic this year.ДЄmong the scientists said to be joining Altos are Juan Carlos IzpisГєa Belmonte, a Spanish biologist at the Salk Institute, in La Jolla, California, who has won notoriety for research mixing human and monkey embryos and who has predicted that human lifespans could be increased by 50 years. Calico also hired elite scientific figures and gave them generous budgets, although itвЂ™s been questioned whether the Google spinout has made much progress. Related StoryДЄltos is certain to draw comparisons to Calico Labs, a longevity company announced in 2013 by Google co-founder, Larry Page. Technology Review confirmed that Milner and his wife Julia have invested in Altos through a foundation. Some people briefed by the company have been told that its investors include Jeff Bezos, the worldвЂ™s richest person, who stepped down as CEO of Amazon in July and weeks later risked his life by jumping into a rocket capsule to reach outer space.

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The new company, incorporated in the US and in the UK earlier this year, will establish several institutes in places including the Bay Area, San Diego, Cambridge, UK and Japan, and is recruiting a large cadre of university scientists with lavish salaries and the promise that they can pursue unfettered blue-sky research on how cells age and how to reverse that process. Altos is pursuing biological reprogramming technology, a way to rejuvenate cells in the lab that some scientists think could be extended to revitalize entire animal bodies, ultimately prolonging human life. That meeting has now led to the formation of an ambitious new anti-aging company called Altos Labs, according to people familiar with the plans. As the scientific sessions progressed, experts took the stage to describe radical attempts at вЂњrejuvenatingвЂќ animals.

But MilnerвЂ™s enthusiasm for science was taking a provocative and specific new direction. Milner is a Russian-born billionaire who made a fortune on Facebook and and previously started the glitzy black-tie Breakthrough Prizes, $3 million awards given each year to outstanding physicists, biologists, and mathematicians. The topic: how biotechnology might be used to make people younger. They were tested for covid-19 and wore masks as they assembled in a theater on the property for a two-day scientific conference. Last October, a large group of scientists made their way to Yuri MilnerвЂ™s super-mansion in the Los Altos Hills above Palo Alto.

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